ASIT as the component of bronchial asthma's therapy can improve the adherence to the treatment.

OBJECTIVE: The aim: To compare the treatment adherence of patients with Bronchial Asthma (BA) receiving basic treatment and its combination with allergen-specific immunotherapy. PATIENTS AND METHODS: Materials and methods: The study included 104 patients aged from 18 to 50 with BA. All patients were divided into two groups. The main group (MG) consisted of 51 patients receiving basic medical treatment and ASIT. 38 of them received subcutaneous ASIT and 13 patients received sublingual ASIT. The comparative group (CG) consisted of 53 patients who received only basic therapy. The patients' observation duration was for a year. RESULTS: Results: All patients were done the computer spirometry with a bronchodilation test, determination of the total IgE level, questionnaires (quality of life, control of asthma, adherence to treatment). Also the major and minor component of allergy house dust mites and specific IgG4 were determined in patients of main groups. After 12 months of observation in both groups the spirometry rates improved (the main group result was 16.9%, the control group - was 12.8%). The indicators of asthma's control also increased (MG by 28%, in CG - 21%, (p <0,05)). After individual conversations and training the patients improved and adherence to the treatment too. In the beginning of our research the mean level in MG was 3.2 ± 0.3 points, in - CG-3.3 ± 0.2 points (p> 0.05), after 12 months it increased to 6.3 ± 0.2 points in MG vs 5. 8 ± 0.1 points in CG (p <0.05). CONCLUSION: Conclusion: Patients' combining basic therapy with SIT had significantly better results of the overall BA's controllability compared to the patients' receiving only basic therapy.

ASIT therapy: advantages and adverse effects. own results and literature data.

OBJECTIVE: Introduction: Allergy is an important medical, social and economic problem nowadays, as it causes disability and patients' quality of life decreases. According to the update data all the existing therapeutic options haven't been used in huge majority of patients. Allergen-specific immunotherapy (ASIT) underuse in particular. One of the reasons for the low frequency of this treatment method using is the fear of systemic and local allergic. The aim of the study was to find out the incidence and severity of adverse reactions in patients receiving subcutaneous and sublingual ASIT. PATIENTS AND METHODS: Materials and methods: In conducted research we compared peculiarities of adverse reactions using sublingual and subcutaneous ASIT methods. Criteria for inclusion in the research were age from 18 to 50 years, diagnosed intermittent or persistent BA. The investigation involved 51 patients with combined basic drug therapy and ASIT, which was performed with injected allergens for 38 patients and sublingual allergens - for 13 individuals. RESULTS: Results: Local reactions were recorded in five patients (13.16%), who received injected ASIT. In four patients (10.52%), dry rales were observed for a short period after injection of the allergen. Local side effect was observed in one patient (7.69%) during sublingual ASIT. CONCLUSION: Conclusions: Adverse reactions, that occur during ASIT, do not pose a threat to patients' lives. However, the therapeutic effect after the year of treatment was significantly better than in patients who used medications only. Modern drugs are safe and, if all the rules are followed, the risk of adverse effects is very low.